Is “Vain” a Scrabble word?

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Yes
VAIN
Valid in at least one Scrabble dictionary

Valid in these dictionaries

SOWPODS / CSW
Scrabble UK & International
Valid
TWL / NWL
Scrabble North America
Valid
Large English Dictionary
General English word list
Valid

Meaning of Vain

/veɪn/

adjective
  1. 1.Overly proud of oneself, especially concerning appearance; having a high opinion of one's own accomplishments with slight reason.

  2. 2.Having no real substance, value, or importance; empty; void; worthless; unsatisfying.

  3. 3.Effecting no purpose; pointless, futile.

    vain toil;  a vain attempt

Synonyms: conceited, inflated, puffed up, fruitless, futile, ineffectual