Is “Tranquiliser” a Scrabble word?

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Yes
TRANQUILISER
Valid in at least one Scrabble dictionary

Valid in these dictionaries

SOWPODS / CSW
Scrabble UK & International
Valid
TWL / NWL
Scrabble North America
Invalid
Large English Dictionary
General English word list
Unavailable

Meaning of Tranquiliser

noun
  1. 1.That which tranquillizes or soothes.

  2. 2.A drug used to reduce anxiety or tension; a sedative.

Synonyms: trank, tranq, tranx