Is “Tire” a Scrabble word?

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Yes
TIRE
Valid in at least one Scrabble dictionary

Valid in these dictionaries

SOWPODS / CSW
Scrabble UK & International
Valid
TWL / NWL
Scrabble North America
Valid
Large English Dictionary
General English word list
Valid

Meaning of Tire

/ˈtʌɪ̯ɚ/

verb
  1. 1.To become sleepy or weary.

  2. 2.To make sleepy or weary.

  3. 3.To become bored or impatient (with).

    I tire of this book.