Is “Sis” a Scrabble word?

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Yes
SIS
Valid in at least one Scrabble dictionary

Valid in these dictionaries

SOWPODS / CSW
Scrabble UK & International
Valid
TWL / NWL
Scrabble North America
Valid
Large English Dictionary
General English word list
Unavailable

Meaning of Sis

/sɪs/

noun
  1. 1.A daughter of the same parents as another person; a female sibling.

    My sister is always driving me crazy.

  2. 2.A female member of a religious order; especially one devoted to more active service; (informally) a nun.

    Michelle left behind her bank job and became a sister at the local convent.

  3. 3.Any butterfly in the genus Adelpha, so named for the resemblance of the dark-colored wings to the black habit traditionally worn by nuns.

Synonyms: affiliate, affiliated, charge nurse, darling, dear, lady