Is “Screwup” a Scrabble word?

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Yes
SCREWUP
Valid in at least one Scrabble dictionary

Valid in these dictionaries

SOWPODS / CSW
Scrabble UK & International
Valid
TWL / NWL
Scrabble North America
Valid
Large English Dictionary
General English word list
Unavailable

Meaning of Screwup

noun
  1. 1.A substantial mistake, usually causing problems for more people than just the person or group who made it.

  2. 2.A person who often makes substantial mistakes; a bungler.

  3. 3.A person who is mentally or emotionally damaged.