Is “Pyxis” a Scrabble word?

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Yes
PYXIS
Valid in at least one Scrabble dictionary

Valid in these dictionaries

SOWPODS / CSW
Scrabble UK & International
Valid
TWL / NWL
Scrabble North America
Valid
Large English Dictionary
General English word list
Valid

Meaning of Pyxis

noun

  1. 1.A small box

  2. 2.A capsule in which the lid separates from the top of the fruit to release the seeds; a pyxidium

  3. 3.A nautical compass

Synonyms: pyxidium

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