Is “Pukes” a Scrabble word?

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Yes
PUKES
Valid in at least one Scrabble dictionary

Valid in these dictionaries

SOWPODS / CSW
Scrabble UK & International
Valid
TWL / NWL
Scrabble North America
Valid
Large English Dictionary
General English word list
Invalid

Meaning of Pukes

noun
  1. 1.Vomit.

  2. 2.A drug that induces vomiting.

  3. 3.A worthless, despicable person.

Synonyms: rotter

verb
  1. 1.To vomit; to throw up; to eject from the stomach.

  2. 2.To sell securities or investments at a loss, often under duress or pressure, in order to satisfy liquidity or margin requirements, or out of a desire to exit a deteriorating market.