Is “Nuke” a Scrabble word?

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Yes
NUKE
Valid in at least one Scrabble dictionary

Valid in these dictionaries

SOWPODS / CSW
Scrabble UK & International
Valid
TWL / NWL
Scrabble North America
Valid
Large English Dictionary
General English word list
Valid

Meaning of Nuke

noun
  1. 1.A nuclear weapon.

  2. 2.(by extension) Something that destroys or negates, especially on a catastrophic scale.

  3. 3.A nuclear power station.

verb
  1. 1.To use a nuclear weapon on a target.

    If a nuclear war ever breaks out, military facilities are likely to be nuked first.

  2. 2.To destroy or erase completely.

    To try to hide his posting history on Usenet, he had his posts nuked from the Google archives.

  3. 3.(by extension) To carry out a denial-of-service attack against (an IRC user).

Synonyms: annihilate, devastate, obliterate