Is “Mules” a Scrabble word?

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Yes
MULES
Valid in at least one Scrabble dictionary

Valid in these dictionaries

SOWPODS / CSW
Scrabble UK & International
Valid
TWL / NWL
Scrabble North America
Valid
Large English Dictionary
General English word list
Unavailable

Meaning of Mules

/mjuːlz/

noun
  1. 1.The generally sterile male or female hybrid offspring of a male donkey and a female horse.

  2. 2.The generally sterile hybrid offspring of any two species of animals.

  3. 3.A hybrid plant.

verb
  1. 1.To smuggle (illegal drugs).

noun
  1. 1.A shoe that has no fitting or strap around the heel, but which covers the foot.