Is “Mono” a Scrabble word?

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Yes
MONO
Valid in at least one Scrabble dictionary

Valid in these dictionaries

SOWPODS / CSW
Scrabble UK & International
Valid
TWL / NWL
Scrabble North America
Valid
Large English Dictionary
General English word list
Valid

Meaning of Mono

noun
  1. 1.A viral infection marked by extreme fatigue, high fever, and swollen lymph nodes.

Synonyms: Pfeiffer's disease, Pfeiffer's glandular fever, glandular fever, infectious mononucleosis, kissing disease, mono