Is “Main” a Scrabble word?

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Yes
MAIN
Valid in at least one Scrabble dictionary

Valid in these dictionaries

SOWPODS / CSW
Scrabble UK & International
Valid
TWL / NWL
Scrabble North America
Valid
Large English Dictionary
General English word list
Valid

Meaning of Main

verb
  1. 1.Short for mainline.

  2. 2.To mainly play a specific character, or side, during a game.

    He mains the same character as me in that game.

  3. 3.Of a road: to convert into a main or primary road.

adjective
  1. 1.Of chief or leading importance; prime, principal.

  2. 2.Chief, most important, or principal in extent, size, or strength; consisting of the largest part.

    main timbers  main branch of a river  main body of an army

  3. 3.(of force, strength, etc.) Full, sheer, undivided.

Synonyms: largest

adverb
  1. 1.Exceedingly, extremely, greatly, mightily, very, very much.