Is “Duodecimo” a Scrabble word?

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Yes
DUODECIMO
Valid in at least one Scrabble dictionary

Valid in these dictionaries

SOWPODS / CSW
Scrabble UK & International
Valid
TWL / NWL
Scrabble North America
Valid
Large English Dictionary
General English word list
Invalid

Meaning of Duodecimo

noun
  1. 1.A size of paper, so called because it is originally made by folding and cutting a single sheet from a printing press into 12 leaves; (5 by 7¾ inches): 6.5 to 7.5 inches high, approximately 4.5 inches wide.

  2. 2.A sheet or page of that size.

  3. 3.A book having pages of that size.

Synonyms: 12mo, 12º, D, twelvemo, 12mo, 12º