Is “Disquisition” a Scrabble word?

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Yes
DISQUISITION
Valid in at least one Scrabble dictionary

Valid in these dictionaries

SOWPODS / CSW
Scrabble UK & International
Valid
TWL / NWL
Scrabble North America
Valid
Large English Dictionary
General English word list
Unavailable

Meaning of Disquisition

/ˌdɪskwɪˈzɪʃ(ə)n/

noun
  1. 1.A methodical inquiry or investigation.

  2. 2.A lengthy, formal discourse that analyses or explains some topic; a dissertation or treatise.