Is “Despond” a Scrabble word?

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Yes
DESPOND
Valid in at least one Scrabble dictionary

Valid in these dictionaries

SOWPODS / CSW
Scrabble UK & International
Valid
TWL / NWL
Scrabble North America
Valid
Large English Dictionary
General English word list
Valid

Meaning of Despond

/dɪˈspɒnd/

noun
  1. 1.Despondency.

Synonyms: despair

verb
  1. 1.To give up the will, courage, or spirit; to become dejected, lose heart.