Is “Derails” a Scrabble word?

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Yes
DERAILS
Valid in at least one Scrabble dictionary

Valid in these dictionaries

SOWPODS / CSW
Scrabble UK & International
Valid
TWL / NWL
Scrabble North America
Valid
Large English Dictionary
General English word list
Unavailable

Meaning of Derails

verb
  1. 1.To cause to come off the tracks.

    The train was destroyed when it was derailed by the penny.

  2. 2.To come off the tracks.

  3. 3.To deviate from the previous course or direction.

    The conversation derailed once James brought up politics.

Synonyms: unrail