Is “Defat” a Scrabble word?

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Yes
DEFAT
Valid in at least one Scrabble dictionary

Valid in these dictionaries

SOWPODS / CSW
Scrabble UK & International
Valid
TWL / NWL
Scrabble North America
Valid
Large English Dictionary
General English word list
Invalid

Meaning of Defat

verb
  1. 1.To remove fat from a material, especially by the use of solvents